SLU-PP-322

Overview

SLU-PP-322 is a small-molecule agonist of estrogen-related receptors (ERRα, ERRβ, ERRγ) — nuclear hormone receptors that function as master transcriptional regulators of oxidative metabolism, mitochondrial biogenesis, and fatty acid oxidation in skeletal muscle, cardiac muscle, and brown adipose tissue. Unlike classical exercise-mimetic compounds, SLU-PP-322 acts directly on the transcriptional machinery governing aerobic metabolism rather than targeting upstream signaling kinases.

By activating ERR family receptors, SLU-PP-322 is hypothesized to upregulate the same gene expression programs induced by endurance exercise — including PGC-1α co-activation, increased mitochondrial density, and enhanced substrate oxidation capacity — without the mechanical stimulation of physical activity.

Research Highlights

Preclinical research in rodent models has demonstrated that SLU-PP-322 administration increases fatty acid oxidation in skeletal muscle, reduces adipose tissue mass, improves cardiovascular endurance metrics, and elevates whole-body energy expenditure. These outcomes parallel what is typically observed following a sustained aerobic exercise training program, leading researchers to characterize it as a pharmacological exercise mimetic with distinct mechanistic properties.

Researchers have also explored its potential in models of metabolic syndrome, type 2 diabetes, obesity, and cardiac dysfunction — conditions where impaired mitochondrial oxidative capacity and reduced ERR activity are implicated in disease progression. Its transcriptional mechanism of action provides a research model complementary to kinase-targeting metabolic compounds like AMPK activators.

For research use only. Not intended for human consumption.

Specifications

Certificate of Analysis

Each batch is independently tested by a third-party laboratory. A Certificate of Analysis (COA) confirming purity and identity is available upon request. Contact us with your order number to receive the COA for your specific lot.