Semax

Overview

Semax is a synthetic heptapeptide analogue of the 4–10 fragment of adrenocorticotropic hormone (ACTH(4-10)), developed by the Institute of Molecular Genetics in Russia. The Met-Glu-His-Phe-Pro-Gly-Pro sequence — particularly the C-terminal Pro-Gly-Pro addition — confers metabolic stability and extends the peptide's duration of action compared to native ACTH fragments.

Semax's primary mechanism of research interest is its documented capacity to stimulate BDNF (brain-derived neurotrophic factor) and NGF (nerve growth factor) expression in hippocampal tissue, engaging neurotrophin signaling pathways that govern synaptic plasticity, neuronal survival, and memory consolidation.

Research Highlights

Preclinical studies have documented Semax's ability to enhance attention, working memory, and learning performance in rodent behavioral paradigms. It has also been studied for its neuroprotective properties in stroke and ischemic brain injury models, where it appears to reduce neuronal apoptosis and support post-injury functional recovery through BDNF-mediated mechanisms.

Researchers have additionally explored Semax's effects on mood regulation and stress response, including its interaction with serotonin and dopamine systems, and its potential role in reducing anxiety-related behaviors. Its nootropic profile — improving cognitive function without stimulant-type side effects — places it in a unique category within neuropeptide research, and it is often compared and contrasted with Selank in dual-compound research protocols.

For research use only. Not intended for human consumption.

Specifications

Certificate of Analysis

Each batch is independently tested by a third-party laboratory. A Certificate of Analysis (COA) confirming purity and identity is available upon request. Contact us with your order number to receive the COA for your specific lot.