Research Peptide
PT-141
A synthetic melanocortin receptor agonist derived from Melanotan II. Acts centrally in the brain to enhance sexual arousal and desire via melanocortin pathways and dopamine — rather than just blood flow. FDA-approved (as Vyleesi) for hypoactive sexual desire disorder in premenopausal women; also researched for male sexual dysfunction.
Overview
PT-141 (bremelanotide) is a synthetic cyclic heptapeptide derived from the melanocortin sequence of alpha-MSH (alpha-melanocyte-stimulating hormone). Unlike vasodilatory compounds that act peripherally, PT-141 exerts its primary effects through central nervous system melanocortin receptor activation — specifically MC3R and MC4R — placing it in a distinct mechanistic category for sexual function research.
Its central mechanism of action makes it an important research tool for investigating the neurobiology of sexual motivation and arousal, as it activates limbic and hypothalamic pathways associated with desire and reward rather than relying on peripheral vascular changes.
Research Highlights
Preclinical and clinical studies have documented PT-141's ability to enhance sexual desire and arousal in both male and female animal models and human subjects, through melanocortin receptor-mediated activation of motivational neural circuits. Its effects on sexual behavior appear to be mediated through dopaminergic pathways downstream of MC4R activation in the hypothalamus.
Research has also explored PT-141's potential applications in models of hypoactive sexual desire disorder (HSDD), characterizing its onset of action, duration of effect, and tolerability profile in controlled study populations. Its CNS-centric mechanism distinguishes it from PDE5 inhibitors and other vasodilatory approaches, providing a complementary research model for understanding central versus peripheral contributions to sexual function.
For research use only. Not intended for human consumption.
Specifications
| Synonyms | Bremelanotide, PT-141 |
| Receptor Targets | MC3R, MC4R (melanocortin receptors) |
| Purity | ≥99% (HPLC verified) |
| Form | Lyophilized powder |
| Storage | −20°C. Stable ≥24 months lyophilized. |
| Origin | USA |
Certificate of Analysis
Each batch is independently tested by a third-party laboratory. A Certificate of Analysis (COA) confirming purity and identity is available upon request. Contact us with your order number to receive the COA for your specific lot.