Research Peptide
NAD+
A critical coenzyme involved in energy production (mitochondrial ATP), DNA repair, sirtuin activation, and redox reactions. Levels drop with age — boosting NAD+ is researched for improved energy, metabolism, cognition, muscle function, and anti-aging effects.
Overview
NAD+ (Nicotinamide Adenine Dinucleotide) is a dinucleotide coenzyme found in all living cells, where it serves as an electron carrier in the mitochondrial electron transport chain and as a substrate for a diverse family of NAD+-consuming enzymes. These include sirtuins (SIRT1–7), which regulate gene expression and metabolism in response to cellular energy status, and PARP enzymes, which mediate DNA damage repair and genomic stability maintenance.
Intracellular NAD+ levels decline with age — by as much as 50% from young adulthood to middle age in multiple tissue types — a trajectory that has been mechanistically linked to mitochondrial dysfunction, impaired DNA repair, and dysregulated metabolic signaling. Restoration of NAD+ levels is a primary focus in translational aging and longevity research.
Research Highlights
Preclinical and emerging clinical research has documented that restoring NAD+ levels can reverse age-associated mitochondrial dysfunction, improve muscle function and endurance, enhance cognitive performance, promote neuronal survival, and modulate inflammatory gene expression through sirtuin-mediated histone deacetylation. Studies in model organisms have also demonstrated lifespan extension following NAD+ precursor supplementation.
Research areas of active investigation include NAD+'s role in circadian rhythm entrainment, its interaction with the DNA damage response pathway via PARP activation, its effects on insulin sensitivity and hepatic lipid metabolism, and its potential neuroprotective properties in models of Parkinson's, Alzheimer's, and other age-associated neurodegenerative conditions. Its central position in cellular energy and signaling makes it one of the most broadly studied molecules in contemporary aging biology research.
For research use only. Not intended for human consumption.
Specifications
| Molecular Weight | ~663.43 g/mol |
| Chemical Formula | C₂₁H₂₇N₇O₁₄P₂ |
| CAS Number | 53-84-9 |
| PubChem CID | 5893 |
| Synonyms | Nicotinamide adenine dinucleotide, Coenzyme I, β-NAD, NADH (reduced form) |
| Purity | ≥99% (HPLC verified) |
| Form | Lyophilized powder |
| Storage | −20°C. Stable 90 days at room temperature lyophilized. Refrigerate after reconstitution. |
| Origin | USA |
Certificate of Analysis
Each batch is independently tested by a third-party laboratory. A Certificate of Analysis (COA) confirming purity and identity is available upon request. Contact us with your order number to receive the COA for your specific lot.