5-Amino-1MQ

Overview

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme expressed at high levels in adipose tissue that catalyzes the methylation of nicotinamide using S-adenosylmethionine (SAM) as the methyl donor. By inhibiting NNMT, 5-Amino-1MQ is hypothesized to increase intracellular SAM availability and shift cellular methyl donor metabolism in ways that influence adipocyte differentiation, lipid storage, and NAD+ recycling pathways.

NNMT activity is elevated in obese adipose tissue and in certain tumor microenvironments, making it an emerging research target for metabolic disease and oncology. 5-Amino-1MQ's selectivity for NNMT inhibition has made it a primary tool compound for investigating the enzyme's biological roles in vivo.

Research Highlights

Preclinical studies in diet-induced obese mouse models have demonstrated that 5-Amino-1MQ treatment produces reductions in fat mass and body weight without significant changes in food intake, suggesting primary effects on energy expenditure and metabolic rate rather than appetite suppression. Researchers have documented increased expression of genes associated with fatty acid oxidation, mitochondrial biogenesis, and thermogenesis in treated adipose tissue.

Research has also explored 5-Amino-1MQ's effects on muscle preservation and lean mass maintenance during caloric restriction models, as well as its potential anti-aging applications through its influence on the methyl donor economy and NAD+ precursor availability. Its orange lyophilized powder appearance is a characteristic property due to the quinolinium chromophore structure.

For research use only. Not intended for human consumption.

Specifications

Certificate of Analysis

Each batch is independently tested by a third-party laboratory. A Certificate of Analysis (COA) confirming purity and identity is available upon request. Contact us with your order number to receive the COA for your specific lot.